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Elevated apoptosis in these neurologic diseases seems to be related to a lack of production of nerve growth factor and to free radical damage

This preserves peptide integrity

This is also suggested by the overexpression of the chaperon GRP78/BiP, which appears to play an important role in the mobilization of Ca 2+ from the ER to the mitochondria 50,55

More serious but less common adverse effects that warrant prompt medical attention include: Acute pancreatitis: Seek urgent medical review if you experience severe, persistent abdominal pain, particularly if it radiates to the back Gallbladder disease: Rapid weight loss associated with GLP-1 class agents may increase the risk of gallstones