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As a long-acting peptide analog, Cagrilintide represents a research subject in the broader field of peptide stability engineering specifically the use of fatty acid acylation strategies to extend peptide half-life and enzymatic resistance compared to native peptide sequences
Combined with the concurrent upregulation of dimethylargininase, which degrades an inhibitor of nitric oxide synthase, has been associated with augmented neovascularization, and was overexpressed 1.5-fold (p=0.002) in semaglutide-treated animals, this constitutes substantial evidence of the relevance of the nitric oxide biosynthetic pathway to an account of the cardiac effects of semaglutide
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hazard ratio [HR], 1.69
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