Environmental hit on a genetic basis in polycystic kidney disease
Vitamin E (800 IU daily) has some evidence supporting its use in non-diabetic adults with biopsy-proven NASH, but this is specialist-initiated, off-label use requiring discussion of potential risks, including increased risk of haemorrhagic stroke and prostate cancer with long-term use
Moving forward, combining natural product research with computational drug discovery, precision medicine, and innovative drug formulations will enhance therapeutic efficacy and accelerate clinical translation
[DOI] [PMC free article] [PubMed] [Google Scholar] Sternberg P, Jr, Davidson PC, Jones DP, Hagen TM, Reed RL, Drews-Botsch C