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The most prevalent form, Distal Symmetric Polyneuropathy (DSPN), results from oxidative damage to Schwann cells and sensory neurons in peripheral nerves (Panou et al., 2025)

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The documented backdrop: at least 8 major research-peptide vendors closed between mid-2025 and early 2026, Peptide Sciences shut down March 6, 2026, and the SAFE Drugs Act introduced in early 2026 targets the retail model the whole category uses