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If baseline ALT or AST levels exceed three times the upper limit of normal (ULN), evaluation for underlying causes is appropriate, though this need not necessarily delay semaglutide initiation if benefits are deemed to outweigh risks
The FDA determined that the tirzepatide shortage was resolved on December 19, 2024, following reevaluation
Therefore, for the insulin regimen subgroup analysis, the treatment policy estimand was used to reflect the effect of initiating treatment with oral semaglutide compared with initiating treatment with placebo, both potentially followed by either discontinuation of the trial product and/or initiation of rescue medication
A reduced dopamine tone within the VTA may thus also contribute to semaglutide's ability to suppress alcohol-related responses
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