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PD-L1 is frequently upregulated in the tumor cell microenvironment as well as in DCs, macrophages, myeloid-derived suppressor cells (MDSCs), and regulatory T cells 87,88,89,90

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Based on these data, PEM and atypical Spitz tumor might represent melanocytic tumors of low-grade (mostly lymphotropic) malignancy different from classical melanoma: it seems thus reasonable to include atypical Spitz tumor into the melanocytoma rubric, as suggested since the beginning (49)