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Besides, in Covid-19, inflammatory signaling pathways like NLRP3 inflammasome and NF-B are highly activated, leading to hyperinflammation and the development of cytokine storms (Al-kuraishy et al

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However, the concept of oral sprays is still at a nascent stage in India

The two arms were reasonably well balanced with respect to the presence of cardiovascular comorbidities (angina, valvular disease, congestive heart failure, hypertension, diabetes, hyperlipidemia, and cardiac revascularization), with the placebo arm having marginally higher rates of cardiac arrhythmia (19% vs 11%), myocardial infarction (MI) (39% vs 30%), and obesity (BMI 30 kg/m 2 78% vs 66%)