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This compound not only inhibited SARM1s NADase activity effectively but also exhibited a favorable safety profile, making it a strong candidate for further development 233
Cell-permeable 2-OG treatment partially phenocopied the effects of ML226, consistent with perturbed OGDHc and 2-OG accumulation stabilizing HIF-1 and decreasing 5hmC levels (Fig
The composition was summarized in Table 1
Macrophages use it to fuel phagocytosis (the process of engulfing and destroying cellular debris and pathogens), while lymphocytes require it to rapidly divide and mount an effective antibody response
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