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However, it is well known that such retrospective observational epidemiological studies on drug effects may be influenced by two main limitations, protopathic bias (i.e., dermatologists were treating presumed psoriatic arthritisPsA) and confounding by indication (i.e., dermatologists tended to use more TNF inhibitors in suspected PsA compared to IL-12/23 inhibitors) [5]
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Together, providing the innate harmful effect of NOS blocker L-NAME itself, these findings may emphasize the positive significance of NO in protecting retinal neurons (and thereby, harmful effect of NOS-blockers ( Furthermore, it was demonstrated that NO is continuously produced in the retina and essential for maintenance of retinal blood flow ( Thereby, while the specific mechanism remains to be further elucidated, a rapid recovering effect on the events going on in the central retinal artery in L-NAME retrobulbar rats may also be possible
Assays were performed in biological replicates (n= 2-9)
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