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Some patients on Contrave do report mild energy shifts from the bupropion component, since bupropion has a slight stimulant-like effect on some people

In this study, Masuda et al

If you are severely deficient in vitamin B12, you might be recommended B12 shots every other day for about two weeks to replenish your B12 stores and correct symptoms

Researchers analyzed the records to find out how many patients developed one of four gastrointestinal conditions and compared that rate to patients using another weight loss drug, bupropion-naltrexone