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With respect to regulated cell death, emerging evidence indicates that both necroptosis and ferroptosis play important roles in the pathogenesis of liver disease [2,3,4,5]

Laboratory studies have demonstrated biological activity at concentrations as low as 0.01 nanomolar, showing measurable effects on fibroblast activity and collagen production even at these minute levels

Materials and methods Animals Adult (810weekold), male C57BL/6 mice (Jackson Laboratories, Bar Harbor, ME) weighing between 20 and 25 g were used

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