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When providers emphasize lifestyle changes before considering medication, they recognize how important these changes are, but may miss the right order of actions

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The increase in the secretion of inflammatory mediators and the reduction of anti-inflammatory factors will further aggravate the immune response, leading to more serious disease progression [17], an effect confirmed by a significantly imbalanced Th17/Treg cell ratio in AR patients [18]

The energy balance defect that causes obesity and visceral adiposity is serious and predisposes individuals to complications, such as atherosclerosis, hepatic steatosis and type 2 diabetes [1]