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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations SAE, sepsis-associated encephalopathy

Finkley, M

Unlike skeletal muscle and heart, which predominantly express Ca 2+ -sensitive isoforms, other tissues, in particular pancreatic islets, have significant expression of Ca 2+ -independent OGDH isoforms, which are thought to be involved in the distribution of 2-oxoglutarate flux to oxidation in the TCA cycle and glutamate biosynthesis (40)