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A: Prior to the advent of Glucagon-like peptide 1 (GLP-1) such as liraglutides and semaglutides and the GLP-1/gastric inhibitory polypeptide (GIP) tirzepatide, long-term pharmacotherapy to achieve body weight normalization along with suitable tolerability and safety remained an insurmountable challenge

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It has also shown certain potential in the treatment of these diseases