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The cytochrome P450 enzyme system is primarily involved in the oxidative pathways where MTZ is biotransformed (Dahl et al

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth

and, for Medicare beneficiaries, drugs like Wegovy and Zepbound will be covered for obesity under certain conditions and beneficiaries will pay just $50 per month in co-pays

As bedaquiline mainly undergoes phase one reactions catalysed by CYP3A4, its exposure may be either reduced or increased during co-administration with inducers or inhibitors of CYP3A4 respectively (Sirturo, 2012)