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doi: 10.1016/j.freeradbiomed.2023.06.009 32 Le GalKWielCIbrahimMXHenricssonMSayinVIBergoMO

Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

BPC 157 has shown low toxicity in animal studies, but long-term human safety data remain limited

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