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These enzymes act synergistically to scavenge superoxide and hydrogen peroxide, thereby limiting ROS-mediated NLRP3 activation and promoting parasite persistence (Harrington and Gurung, 2020)

NAMPT inhibitors are primarily explored for their anti-cancer properties, as they reduce NAD + levels and impair energy metabolism and survival of cancer cells 214

Integrated therapeutic strategies that co-activate these pathways, such as dual-metallic nanosystems or glucose metabolism-targeting agents, demonstrate enhanced antitumor efficacy by overcoming compensatory resistance mechanisms