Despite this lack of relationship between mutations, or deficiency, in apoptotic genes and SLE, there is agreement that apoptosis plays an important role
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Abbreviations ALL: Acute lymphoblastic leukemia Met: Metformin CQ : Chloroquine AraC : Cytarabine MDA : Malondialdehyde FRAP: Ferric reducing antioxidant ability DPPH: 2,2-Diphenyl-1-picrylhydrazyl allo-HSCT : Allogeneic hematopoietic stem cell transplantation CAR-T: Chimeric antigen receptor T-cell WHO: World Health Organization AMPK : Adenosine monophosphate-activated protein kinase HDF: Human dermal fibroblast FBS : Fetal bovine serum PBS: Phosphate-buffered saline FITC: Fluorescein isothiocyanate PI: Propidium iodide qRTPCR: Quantitative real-time polymerase chain reaction TAC: Total antioxidant capacity GSH: Reduced glutathione GSSG : Oxidized glutathione OD: Optical density DTT: Dithiothreitol HCQ : Hydroxychloroquine PARP: Poly ADPribose polymerase References Dander, E., Palmi, C., DAmico, G
Crucially, wild-type MZB are known to be prone to activation compared to FoB 7,8,75 , and we found that both Gclc fl/fl Mb1-Cre + FoB and B6 MZB showed a similar increase in mitochondrial mass (Fig
