This widespread vascular impairment is a primary driver of the severe fatigue, brain fog, and post-exertional malaise (PEM) experienced by patients, as their cells are literally starved of the resources needed to generate energy
These results suggest that CaM/CaMKII is involved in the exendin-4 effect on GABA currents
Some individuals may have difficulty absorbing B12 from dietary sources, making injections necessary
I ran a biochemical optimization program a while back, and one of the clients that I had in there, he tried methylene blue, and he only got up to a half a milligram or a milligram, and his mood was worse, his fatigue was worse, he had more anxiety, a bunch of problems that, you know, the dose was too low to say it was doing a pharmacological messing with his neurotransmitters