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Consistent with nicotines anti-inflammatory effects, chronic nicotine administration via an osmotic minipump did not increase either TNF- or IL-1 in the nucleus accumbens in male mice (160), thereby supporting the notion that the constituents in the JUUL pods, or the interaction of nicotine with the constituents, led to the changes in inflammatory markers

Increased Heart Rate and Blood Pressure Nicotine activates the sympathetic nervous system, and this causes a transient elevation in blood pressure and heart rate

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Nicotine Replacement Therapy (NRT) is a cost-effective intervention Any intervention to help somebody quit smoking is a cost-effective intervention, as it supports the health of the patient: 72 hours after quitting breathing may become easier and energy levels could increase 20 2-12 weeks after quitting blood circulation could improve 20 1 year after quitting the risk of heart attack has halved compared to a smoker 20 10 years after quitting the risk of lung cancer falls to around 50% of that of a smoker 20 By improving the patient's health in the long term, the costs to the NHS are also reduced 21