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18 conducted their study in the United States, using high-dose nicotine patches, while Raja et al

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Some of the colon cancer signs that may appear as the cancer advances to different stages include: Blood in the stool Sudden and unexplained fatigue, weakness, and weight loss Constant abdominal pain, cramps, and gas Diarrhea or constipation that lasts more than four weeks Painful bowel movements and a feeling of not emptying completely Constant urge to defecate and a change in stool consistency These symptoms resemble the symptoms of other illnesses and diseases