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This reduced insulin demand may slow the progressive beta cell exhaustion that worsens diabetes over time

This mechanism lowers blood glucose levels and has shown modest weight loss benefits in clinical trials, typically 24 pounds on average

Two other studies involving 206 exposed pregnancies and 267 comparator pregnancies showed no evidence of an association with spontaneous abortion (OR 0.95

In practical terms, for a patient starting at 200 pounds: Semaglutide at full dose: average expected loss of 28 to 34 pounds over 12 to 18 months Tirzepatide at full dose: average expected loss of 38 to 48 pounds over 12 to 18 months These are not the results of crash diets