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Additionally, a series of genes related to osteogenic differentiation ability were highly expressed in these cells during the process of osteogenic induction, including alkaline phosphatase ( Alp ), osteopontin ( Opn ), osterix ( Osx ), bone morphogenetic protein 2 ( Bmp2 ), runt-related transcription factor 2 ( Runx2 ) (Supplementary Fig

He observed that the peptide complexed with copper could influence gene expression, helping older tissue behave more like younger tissue [2]

Traditional approaches like nonsteroidal anti-inflammatory drugs (NSAIDs) suppress inflammation broadly, which may actually impair long-term tissue healing

If serum free copper rises above 25 mcg/dL, discontinue and reassess [2]