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Total secreted A38 levels were elevated compared to WT controls, while A40 levels remained unchanged

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Elevations in systemic iron levels trigger a corresponding upregulation in the synthesis of the regulatory hormone hepcidin ( 2+ to Fe 3+ , a prerequisite for systemic iron transport ( 3+ ) is subsequently chelated by transferrin, a key plasma glycoprotein, which enables its safe and targeted delivery to tissues via the systemic circulation ( As central regulators, mitochondria coordinate ferroptotic progression by modulating iron homeostasis, amplifying reactive oxygen species (ROS), and undergoing functional compromise