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Site rotation across these regions on a weekly basis is standard practice for all once-weekly subcutaneous peptide administrations, and is particularly important during extended retatrutide dosing studies where repeated injection at a single site can cause localized lipodystrophy or reduced absorption efficiency

As finalized, 427.201(a) establishes that CMS will use the methodology established in such section to calculate the inflation-adjusted beneficiary coinsurance and associated adjusted Medicare payment percentage and incorporates references to the existing provisions at 410.152(m), 419.41(e), and 489.30(b)(6)

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