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current smokers for CCs, and both occasional and regular current users for ECs and HTPs) were asked whether they experienced one or more of a structured list of a priori defined adverse events that could be associated with the use of the product, either during or after its use 18 : dry cough, sore throat, mouth dryness, vertigo, headache, constriction of the respiratory tract, mouth irritation, nausea, dizziness, burns to the lips, mouth ulcers, and other adverse effects

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17 Although there have been concerns about neuropsychiatric adverse effects with varenicline, the evidence from a recent meta-analysis is that, compared with placebo, there is no increase in rates of suicidal events, depression or aggression/agitation in patients taking varenicline