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106 HIF signaling pathway Hypoxia-inducible factors (HIFs), consisting of an oxygen-sensitive subunit and a constitutively expressed HIF-1 subunit, are major regulators of adaptive responses to hypoxia and directly activate the expression of multiple target genes to maintain cellular oxygen homeostasis
Pre-clinical and cosmetic-research data describe increased collagen and elastin synthesis, fibroblast proliferation, improved barrier-protein expression, and reduced markers of oxidative stress following GHK-Cu exposure
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