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While those products have not been specifically authorized for sale, the FDA has indicated by words and actions that it will not enforce against them while their PMTAs or legal challenges are pending

According to an April 2004 study, gingival (gum) blood flow rate was "significantly higher at 3 days" and within 5 days the liquid sticky plasma proteins normally released by healthy gums (gingival crevicular fluid) had significantly increased and within 2 weeks were comparable to those of non-smokers

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An assay measuring the abundance of H2AX in human bronchial epithelial cells can, therefore, be used to evaluate whether the extent of DNA double-strand breaks caused by the cMRTP aerosol is lower than that caused by cigarette smoke [47, 48]