Given that studies have failed to find an association between CYP2D6 polymorphism and incidence of depression (178), the most likely conclusion is the latter, in which individuals have an increased need to try different therapeutics in search of a positive therapeutic response (176, 177)
Adolescents who smoke e-cigarettes are more likely to form friendships, making it harder for them to quit 31
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In children, and sometimes adults, lesions are annular / polycyclic, often with blistering around the edge known as the 'string of pearls' sign Refer to the related chapter Linear IgA disease Erythema multiforme Can become generalised - refer to the notes in the section below on hands / forearms Epidermolysis bullosa acquisita - generalised inflammatory type (figure 30) This is extremely rare Findings are similar to bullous pemphigoid Refer to the related chapter Epidermolysis bullosa acquisita Bullous systemic lupus erythematosus (figure 31) Is an immunobullous condition, usually arising in patients with well-established SLE The blistering is widespread, although in some patients the eruption is photosensitive Lesions vary in size from vesicles to large bullae Mucosal lesions are uncommon Histologically the blisters are subepidermal
