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Lactate concentrations increase with increasing hydrogen ion concentrations 31 and therefore the reduction in lactate and increase in BAs further supports our hypotheses, and suggest that bacteria present in low- Lactobacillus CST-IV use available hydrogen ions to perform amino acid decarboxylation and produce BAs, thus resisting acid stress 56

New thinking for the 21st century Chapter 7: Final thoughts The Right Side of History: The Global State of Tobacco Harm Reduction 2022 The Right Side of History: The Global State of Tobacco Harm Reduction 2022 does not seek to replicate or revisit the previous GSTHR reports in detail

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Segments Covered in the Report 1