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In Italy one of the worlds first test markets for Philip Morris Internationals IQOS (a HTP device that was first launched there and in Japan in 2014) adult smoking remains high 5 , and uptake of EC and HTP has grown since they were introduced to the market 6

Thus, compared to the general population, tobacco smoking is about 23 times more frequent in BD ( More in detail, data from the US National Comorbidity Survey indicate that the lifetime prevalence of daily smoking among adults with BD is 59%, and thus significantly higher in comparison to that of adults without mental disorders (39.1%) ( Finally, metanalytic analysis of three cross-sectional studies [one population based ( Little data has been published differentiating between Bipolar I (BD-I) and Bipolar II (BD-II) patients

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