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consequently, they tend to smoke more heavily The smoking causes schizophrenia hypothesis proposes that smoking is a risk factor for developing psychosis The shared genetic vulnerability hypothesis suggests that common genes increase the risk of developing both schizophrenia and nicotine dependence It is evident that the self-medication hypothesis, the smoking causes schizophrenia hypothesis and the shared genetic vulnerability hypothesis are not mutually exclusive, and that all three may contribute to the observed higher prevalence of smoking in people with schizophrenia