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Why Your Body Holds Onto Nicotine (And Why It Matters) The Two-Phase Problem Nobody Explains When you use nicotinewhether from cigarettes, vapes, pouches, or gumyour body immediately begins a two-phase process: Phase 1: Nicotine Processing (1-4 hours) Nicotine hits your bloodstream Half-life of 1-2 hours (50% gone) Liver converts it to cotinine You feel the effects wearing off Phase 2: Cotinine Clearance (Days to Weeks) Cotinine half-life: 16-20 hours Stores in fat cells, organs, and hair What drug tests actually measure Determines your "clean" timeline The Metabolite That Ruins Everything: Cotinine Here's the plot twist: nicotine tests don't test for nicotine

Access this article Similar content being viewed by others Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request

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