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7 Compared with placebo, patients taking metformin had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years)

With a number of GLP-1 medications in Phase 2 trials, we believe that the winning formula to stand out in a crowded landscape will be to combine medication with advanced behavior change to drive differentiated outcomes, while proving it with Phase 4 studies

Head-to-head comparative trials examining inflammatory outcomes as primary endpoints are limited, and most evidence comes from individual studies or post-hoc analyses of cardiovascular outcome trials