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1, 5 Pharmacological therapies There is some evidence to support the use of acetylcholinesterase-inhibitors, and some other antidementia drugs 1- 3 Non-pharmacological therapies Cognitive training routines have been investigated to improve cognition in PD 1 Some evidence suggests that physical exercise can improve non-motor symptoms, including cognition in patients with PD 1 Again, some studies have suggested deep brain stimulation could be effective in patients with PD and cognitive symptoms 1

Therefore, a combination of transcellular and paracellular routes for crossing the nasopharyngeal barrier is also possible if the meningococci crossing via the transcellular route induce a sufficient level of inflammation to alter epithelial permeability, allowing other bacteria to follow the paracellular route

By contrast, topical doxepin mouthwash has proven analgesic efficacy for radiation-induced oral mucositis pain in head-and-neck cancer, butbased on current evidencehas not been evaluated as a BMS-specific therapy and was therefore not used here as a direct comparator 20