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It inhibits kidney fibrosis and damage induced by LPS, aristolochic acid I, Cisplatin, adenine, adriamycin, Ang II, excessive fructose, unilateral ureteral obstruction, and 5/6 nephrectomy through its antioxidant and anti-inflammatory properties, as well as by modulating mitochondrial pathways

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One study on women looking at colon cancer risk found that women with a high polygenic risk score for colon cancer had a significant reduction in risk of CRC with menopausal HRT.[ref] Another study showed that several genetic variants statistically impacted the risk of breast cancer with HRT, but it concluded that more studies are needed