is pure tobacco cancerous World Cancer Day 2017 – ASH > Action on Smoking & Health Tobacco Use and Oral Health:

The result will be longer and healthier lives for all people. During 2006 to 2019, among adults with past-year major depressive episodes or substance use disorder, past-month cigarette smoking declined significantly across every examined age, sex, and racial and ethnic subgroup, except that among non-Hispanic American Indian or Alaska Native adults smoking rates did not decline

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One complication in interpreting the available evidence is the temporality of the associations of smoking with the various disorders