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In extreme cases, studies on germ-free animals confirmed that the lack of intestinal microbiota would lead to the degradation of intestinal mucosal barrier function, the specific manifestations are the reduction of the overall intestinal surface area, shorter intestinal villi, the reduction of intestinal crypt, the increase in intestinal permeability as well as the thinning and instability of mucous layer [81, 82]

In clinical trials, some GLP-1 medications have helped patients lose 1520% of their body weight, making them a significant advancement in weight management

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