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Is it possible we are missing a treatment effect of Lixisenatide because of the heterogeneity present in most Parkinsons groups recruited for clinical trials (in other words Parkinsons is not one disease and we may have recruited a few different subtypes and this watered down the potential effects)

Off-label prescribing is legal in many countries, including the United States, as long as the doctor believes that the medication may benefit the patient

Di Odoardo LAF, Zucchetti O, Sciatti E, DIsa S, DElia E, Senni M

There was insufficient evidence for them to conclude that vitamin C helped prevent problems during pregnancy, such as stillbirth, preterm birth, or preeclampsia