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For the modification with the 18F, the ion exchange method with 18F will preferably be used taking into account: - de la courte dure de vie moyenne du 18F- the short average life of the 18F - de la difficult de synthtiser des ligands fluors base de 18F - l'imagerie TEP ne ncessite pas beaucoup de fluor, donc avec la quantit lie comme contre-ion sera suffisante.the difficulty of synthesizing fluorinated ligands based on 18F - PET imaging does not require a lot of fluorine, so with the amount bound as counter-ion will be sufficient