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REFERENCES (1) Food and nicotine metabolism (2) Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation (3) Does Drinking Water Flush Nicotine Out of Your System

In the case of multiple waves of follow-up data, evidence of a positive baseline e-cigarette use by time interaction term for either smoking status, frequency, or intensity would indicate that e-cigarette use is associated with increased likelihood or speed of progression in the respective outcome, whereas a negative interaction term would indicate that e-cigarette use is associated with reduced likelihood or speed of progression