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Unlike any other medicine in the GLP-1 class today, semaglutide is the only molecule whose respective FDA indications span obesity, type 2 diabetes, liver disease, kidney disease and cardiovascular risk, the statement read

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The two compounds activate distinct somatotroph receptors (GHRH-R and GHS-R1a), producing additive GH release in published rodent and primate models without the cortisol or prolactin spillover seen with earlier GHRPs, because they couple to different intracellular signalling cascades