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Kidney Screening Here are some of the possible ways smoking is thought to harm kidneys: Increases blood pressure and heart rate Reduces blood flow in the kidneys Increases production of angiotensin II (a hormone produced in kidney) Narrows the blood vessels in the kidneys Damages arterioles (branches of arteries) Forms arteriosclerosis (thickening and hardening) of the renal arteries Accelerates loss of kidney function In addition to tobacco, smoking allows other toxins into the body