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Outcomes were classified as critical, important but not critical, or of limited importance based on the GRADE methodology.6 To enhance efficiency, existing systematic reviews were initially identified for the formulation of all pharmacotherapy and most non-pharmacotherapy questions using the Cochrane Library and Epistemonikos

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This review examines the disruption of microbial ecosystems by smoking, with a focus on the imbalance between beneficial and pathogenic microorganisms

They found that over 6,000 CpGs were differentially methylated in offspring exposed to maternal smoking including several genes that were critical in development [49]