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Sample Handling in Turku University Hospital Auria BioBank Pathology Collection All blood samples were taken from BioBank storage after given informed consent from patients

Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 2a genetic neurodegenerative disorder due to a CAG repeat expansion mutation in the ATXN2 gene coding for the protein ataxin-2 63 has been associated to oxidative stress, in particular due to alterations in the enzymatic activity of antioxidant enzymes including GSTs 64

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By 8 weeks, the mean stratum corneum hydration significantly increased from 43.7 to 51.7, along with skin elasticity in the treatment group