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Mostly, its the unknown, the FDA says

The Elf Bar BC5000 gives 5000 puffs, equaling about 300350 cigarettes, depending on usage and absorption

Because vaping aerosols are created with heat, Unwanted chemical reactions can produce more chemical substances, such as formaldehyde, acetaldehyde, benzene, toluene, and metals, some of which are harmful to our body, said Yang Wang, a University of Miami environmental engineering professor

Loose pipe tobaccos generally lack many, if not all, of the approximately 600 ingredients which are added to most cigarette tobaccos, including cancer-causing chemicals like tar, carbon monoxide, arsenic and benzene