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What antihistamines DON'T do: They don't reduce mast cell activation or degranulation They don't decrease the amount of histamine being released They don't support the enzymes that break down histamine They don't address any of the other mediators released by mast cells (leukotrienes, prostaglandins, cytokines, tryptase) This is why symptoms come roaring back the moment your antihistamine wears off all that histamine is still there, along with everything else