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ROS can be described as oxygen free radicals and other non-radical oxygen derivatives involved in oxygen radical production [4], which are generated by the cells in most tissues and involved in normal cellular metabolism [5]

Peeling the onion: The outer layers of Cryptococcus neoformans

Using a V3S1/V13S1 T-cell receptor (TCR) from a lesional psoriatic CD8 + T-cell clone we had discovered that, as an underlying pathomechanism, HLA-C*06:02 mediates an autoimmune response against melanocytes in psoriasis, and we had identified an epitope from ADAMTS-like protein 5 (ADAMTSL5) as a melanocyte autoantigen

Experimental work described by Patt et al