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In this ancestral polyploid event, duplication of polyamine and nicotinamide adenine dinucleotide pathways resulted in gene redundancy, reduced selection pressure on these pathways, and promoted the emergence of the novel alkaloid, nicotine [63]

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In contrast to cigarettes, where the principal focal point of malignant growth improvement is as a rule in the mouth, lips, throat, and lungs, nicotine ingested in alternate ways expands the chance of disease in a more broad sense

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