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During World War II, it was marketed in Japan as hiropon , a word that combines the Japanese terms for fatigue and fly away. Hiropon was given to Japanese soldiers to increase alertness
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This has been suggested to stem from an increased propensity for base excision repair (BER), as colorectal cancers with low expression of the BER mediator excision repair cross-complementing (ERCC1) have been shown to have increased sensitivity to Oxaliplatin (257)
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